Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp47 | Bone development/growth and fracture repair | ECTS2014

Mechanisms of action and osteogenic activity of bone marrow mesenchymal stromal cells are donor dependent

Leotot Julie , Lebouvier Angelique , Hernigou Philippe , Rouard Helene , Chevallier Nathalie

Human mesenchymal stromal cells (hMSC) have been investigated as a clinical therapy to promote tissue repair. However, the disappearance of grafted cells soon after engraftment suggests that hMSC could principally act as initiators of repair through paracrine mechanisms.The aim of this study was to evaluate the relative contribution of grafted hMSC and host cells in promoting bone tissue repair. We isolated hMSC from three bone marrow (BM) donors, then d...